汪维瀚

 

    

汪维瀚  研究员

1455783979246701.jpg1992年-1995年,伦敦帝国学院,荣誉学士(一级)

2003年-2007年,瑞士联邦理工学院洛桑,博士

2007年-2009年,美国麻省理工学院,博士后

 

电邮:chmawh@nus.edu.sg


个人网页http://weehan.sgresearcher.net/


研究领域

生物无机/生物金属有机/药物化学/含金属药物/药物递送。我的研究兴趣主要集中于开发具有高选择活性的金属药物制剂。为此,我们应用纳米复合材料作为载体来实现靶向递送和定向诱导,以期减少临床药物所普遍面临的毒性和耐药性的问题。同时我们也期望采用纳米材料技术来阐明金属药物作用的基本机制。

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代表性论文

1. F. Chin, S. Q. Yap, J. Li, G. Pastorin*, W. H. Ang*, Ratiometric delivery of cisplatin and doxorubicin using tumour-targeting carbon-nanotubes entrapping platinum(IV) prodrugs, Chem. Sci., 2014, in press

2. L. Yoong, B. S. Wong, Q. L. Zhou, C. F. Chin, J. Li, T. Venkatesan, H. K. Ho, V. Yu, W. H. Ang*, G. Pastorin*, Enhanced cytotoxicity to cancer cells by mitochondria-targeting MWCNTs containing platinum(IV) prodrug of cisplatin, Biomaterials, 2014,35, 748-753

3. Montagner, S. Q. Yap, W. H. Ang*, A fluorescent probe for investigating the activation of anticancer platinum(IV) prodrugs based on the cisplatin scaffold, Angew. Chem. Int. Ed., 2013, 52, 11785-11789

4. Paira, M. J. Chow, G. Venkatesan, V. K. Kosaraju, S. L. Cheong, K.-N. Klotz, W. H. Ang*, G. Pastorin*, Organoruthenium antagonists of human A3 adenosine receptors, Chem. Eur. J., 2013, 19, 8321-8330

5. F. Chin, Q. Tian, M. I. Setyawati, W. Fang, E. S. Q. Tan, D. T. Leong, W. H. Ang*, Tuning the activity of platinum(IV) anticancer complexes through asymmetric acylation, J. Med. Chem., 2012, 55, 7571-7582

6. Li, S. Q. Yap, C. F. Chin, G. Pastorin*, W. H. Ang*, Platinum(IV) prodrugs entrapped within multiwalled carbon nanotubes: Selective release by chemical reduction and hydrophobicity reversal, Chem. Sci., 2012, 3, 2083-2087

7. X. Ong, C. W. Yap, W. H. Ang*, Rational Design of Selective organoruthenium inhibitors of protein tyrosine phosphatase 1B, Inorg. Chem., 2012, 51, 12483-12492

8. Tian, W. Wong, Y. Xu, Y. Chan, H. K. Ho, G. Pastorin, W. H. Ang*, Immobilisation of quantum dots by bio-orthogonal PCR amplification and labelling for direct gene detection and quantitation, Chem. Commun., 2012, 48, 5467-5469

9. Y. Q. Wong, J. Y. Lau, W. H. Ang*, Harnessing chemoselective imine ligation for tethering bioactive molecules to platinum(IV) prodrugs, Dalton Trans., 2012, 41, 6104-6111

10. Q. Tan, P. J. Dyson, W. H. Ang*, Acetal-Functionalized RAPTA Complexes for Conjugation and Labeling, Organometallics, 2011, 30, 5965-5971


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