王锡民

 

王锡民  首席研究员

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学士(1980),南洋大学,新加坡(现南洋理工大学)

硕士(1983),西弗吉尼亚大学,美国

博士(1987),康奈尔大学,美国


电邮: sciwsm@nusri.cndbswsm@nus.edu.sg



研究领域

植物病毒分子生物学,对新病毒的发现,病毒的复制和翻译机制,快速灵敏的病毒检测,病毒间的协同作用和病毒与宿主间的相互作用,病毒新基因的功能,利用植物病毒作为载体的蛋白表达,抗病毒转基因植物,病毒的结构生物学和生物信息学,利用植物病毒作为输送药物的纳米材料,RNA干扰。


代表性论文

1. Liu P, Wang L, Wan ZY, Ye BQ, Huang S, Wong SM, Yue GH (2016). Mapping QTL for resistance against viral nervous necrosis disease in Asian Seabass. Marine Biotechnol. 18: 107-116. doi: 10.1007/s10126-015-9672-6.

2. Guo S, Kierzek E, Chen G, Zhou Y-J, Wong S-M. (2015).  TMV mutants with poly(A) tracts of different lengths demonstrate structural variations in 3’UTR affecting viral RNAs accumulation and symptom expression. Sci. Rep. 5: 18412; doi: 10.1038/srep18412.

3. Li S, Wang S, Wang X, Li X, Zi J, Ge S, Cheng Z, Zhou T, Ji Y, Deng J, Wong S-M, Zhou Y (2015). Rice stripe virus affects the viability of its vector offspring by changing developmental gene expression in embryos. Sci. Rep. 5: 7883 doi:10.1038/srep07883.

4. Niu S, Cao S, Huang LJ, Tan KCL and Wong SM (2015). The length of an internal poly(A) tract of Hibiscus latent Singapore virus is crucial for its replication. Virology474:52-64.

5. Niu S, Gil-Salas FM, Tewary SK, Samales AK, Johnson J, Swaminathan K and Wong SM (2014) Hibiscus chlorotic ringspot virus coat protein is essential for cell-to-cell and long-distance movement but not for viral RNA replication. PLoS ONE 9(11): e113347. doi:10.1371/journal.pone.0113347.

6. Gao RM, Xie JT, Lin QS, Seow TK, Wong SM (2014). Identification of differentially expressed proteins in TCV-infected Nicotiana benthamiana protoplasts determined by 2-D gel electrophoresis. Plant Pathology Bulletin 23(1): 15-29.

7. Niu SN, Cao SS, Wong SM (2014). An infectious RNA with a hepta-adenosine stretch responsible for programmed -1 ribosomal frameshift derived from a full-length cDNA clone of Hibiscus latent Singapore virus. Virology 449: 229-234.


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