教育背景
2002-2006 北京师范大学化学系,学士
2006-2012 波士顿大学化学系,博士
工作经历
2012-2015 麻省理工化学系,化工系联合培养SkolTech,博士后
2015-2015 Snapdragon Chemistry, Inc. 波士顿,高级研究员
2015-2021 新加坡国立大学化学系,助理教授
2021-至今 新加坡国立大学化学系,副教授
研究领域
1. 流动有机合成
2. 光催化合成
3. 自动合成
荣誉、奖项
2017-2019年 Asian Core Program Lectureship Award (Korea, Thailand, Taiwan, China)
2018年 NUS Chemistry Department Young Chemist Award
2019年 Thieme Chemistry Journal Award
2020年The Distinguished Lectureship Award, The CSJ Asian International Symposium, The Chemical Society of Japan
代表性论文
[1] Cai, B.; Cheo, H. W.; Liu, T.; Wu,
J.* “Light-promoted Carbon-Carbon Bond Formation Utilizing Natural Gases as
Feedstocks” Angew. Chem. Int. Ed. 2020, accepted. DOI: 10.1002/anie.202010710
[2] Wang, H.; Toh, R. W.; Shi, X.; Wang, T.; Cong, X.; Wu, J.* “Photo-mediated Selective
Deconstructive Geminal Dihalogenation of Trisubstituted Alkenes” Nat.
Commun. 2020, 11, 4462
[3] Kuang, Y.; Cao, H.; Tang, H.; Chew, J.; Chen, W.; Shi, X.; Wu, J.* “Visible Light Driven
Deuteration of Formyl C-H and Hydridic C(sp3)-H Bonds in Feedstock Chemicals
and Pharmaceutical Molecules” Chem. Sci. 2020, 11, 8912-8918
[4] Yan, J.; Cheo, H. W.; Teo, W. K.; Shi, X.; Wu, H.; Idres, S. B.;
Deng. L.-W.; Wu, J.* “A Radical Smiles
Rearrangement Promoted by Neutral Eosin Y as a Direct Hydrogen Atom Transfer
Photocatalyst” J. Am. Chem. Soc. 2020, 142,
11357-11362 (Highlighted by Rational Science and X-MOL)
[5] Zhang, Y.; Yang, X.; Wu,
J.*; Huang, D.* “Aerobic C-H Functionalization Using Pyrenedione as the
Photocatalyst” Synthesis 2020, DOI: 10.1055/s-0040-1707135
[6] Zheng, L.; Xue, H.; Wong, W. K.; Cao, H.; Wu, J.*; Khan, A. S.* “Cloud-inspired Multiple Scattering for
Light Intensified Photochemical Flow Reactors” React. Chem. Eng. 2020, 5, 1058-1063
[7] Jia, P.; Li, Q.; Poh, W. C.; Jiang, H.; Liu, H.; Deng, H.; Wu, J.* “Light-Promoted Bromine Radicl-Mediated
Selective Alkylation and Amination of Unactivated C(sp3)-H Bonds” Chem 2020, 6, 1766-1776
[8] Cao, H.; Kuang, Y.; Shi, X.; Wong, K. L.; Tang, B. B.; Kwan, J. M.
C.; Liu, X.; Wu, J.* “Photoinduced
Site-Selective Alkenylation of Alkanes and Aldehydes with Aryl Alkenes” Nat.
Commun. 2020, 11, 1956 (Highlighted by Synfacts
2020, 16, 0795 and chosen as Synfacts of the month. It has been higlighted by
iCat, Phys. Org, Organic Chemistry Portal, and National University of Singapore
(Suzhou) Research Institute)
[9] Xu, W.; Jiang, H.; Leng, J.; Ong, H.-W.; Wu, J.* “Visible-Light-Induced Selective Defluoroborylation of
Polyfluoroarenes, gem-Difluoroalkenes, and Trifluoromethylalkenes” Angew.
Chem. Int. Ed. 2020, 59, 4009-4016 (Highlighted
by Rational Science and X-MOL)
[10] Zhang, Y.; Yang, X.; Tang, H.; Liang, D.; Wu, J.*, Huang, D.* “Pyrenediones as Versatile Photocatalysts for
Oxygenation Reactions with in situ Generation of Hydrogen Peroxide under
Visible Light” Green Chem. 2020, 22, 22-27
[11] Liu, R.; Chia, S. P. M.; Goh, Y. Y.; Cheo, H. W.; Fan, B.; Li, R.;
Zhou, R.*; Wu, J.* “Visible‐Light‐Mediated
Regioselective Allylation, Benzylation, and Silylation of
Methylene‐Malononitriles via Photoredox‐Induced Radical Cation Fragmentation” Eur.
J. Org. Chem. 2020, 10, 1459-1465
[12] Kuang, Y.; Wang, K.; Shi, X.; Huang, X.; Meggers, E.; Wu, J.* “Asymmetric Synthesis of
1,4‐Dicarbonyl Compounds from Aldehydes via the Marriage of Hydrogen Atom
Transfer Photocatalysis with Chiral Lewis Acid Catalysis” Angew.
Chem. Int. Ed. 2019, 58, 16859-16863 (Highlighted
by WeeChem and X-MOL)
[13] Fan, X.; Xiao, P.; Jiao, Z.; Yang, T.; Dai, X.; Xu, W.; Tan, J.
D.; Cui, G.*, Su, H.; Fang, W.; Wu,
J.* “Neutral-Eosin-Y-Photocatalyzed Silane Chlorination Using Dichloromethane” Angew.
Chem. Int. Ed. 2019, 58, 12580 (Highlighted by
X-MOL)
[14] Zhou, R.; Li, J.; Cheo, H. W.; Chua, R.; Zhan, G.; Hou, Z.; Wu, J.* “Visible-Light-Mediated
Deuteration of Silanes with Deuterium Oxide” Chem. Sci. 2019, 10,
7340-7344 (Featured as back cover in Chemical Science)
[15] Xu, J.-H.; Wu, W.-B.; Wu,
J.* “Photoinduced Divergent Alkylation/Acylation of Pyridine N-Oxides with
Alkynes under Anaerobic and Aerobic Conditions” Org. Lett. 2019, 21,
5321-5325
[16] Ou, W.; Zhang, G.; Wu,
J.; Su, C.* “Photocatalytic Cascade Radical Cyclization Approach to
Bioactive Indoline-Alkaloids over Donor-Acceptor Type Conjugated Microporous
Polymer” ACS Catal 2019, 9, 5178-5183.
[17] Wong, Y.-C.; Wu, W.-B.; Wang, T.; Ng, J. D. A.; Khoo, K. H.*; Wu, J.*; Tan, Z.-K.* "Color Patterning
of Luminescent Perovskites via Light‐Mediated Halide Exchange with Haloalkanes" Adv.
Mater. 2019, 31, 1901247
[18] Wu, J.* “Young Career
Focus: Dr. Jie Wu (National University of Singapore, Singapre).” Synform 2019, 05, A68-A70
[19] Ng. C. K.; Toh, R. W.; Lin, T. T.; Luo, H.; Hor, T. S. A.*; Wu, J.* “Metal-Salen Molecular Cages as
Efficient and Recyclable Heterogeneous Catalysts for Cycloaddition of CO2 with
Epoxides at Ambient Conditions.” Chem. Sci. 2019, 10, 1549-1554 (Highlighted by Synfacts 2019, 15, 0540)
[20] Li, J.; Luo, Y.; Cheo, H. W.; Lan, Y.*; Wu, J.* “Photoredox Catalysis Modulated Nickel-Catalyzed Divergent
Difunctionalization of Ethylene” Chem 2019, 5, 192 (Highlighted by X-MOL, NUS FoS, and Phys.Org)
[21] Xue, C.; Li, J.; Lee, J. P.; Zhang, P.*; Wu, J.* “Continuous Amination of Aryl/Heteroaryl Halides Using
Aqueous Ammonia in a Teflon AF-2400 Tube-in-Tube Micro-Flow Reactor.” React.
Chem. Eng. 2018, 4, 346-350 (Invited article
for special issue “RCE Emerging Investigator 2019”)
[22] Cao, H.; Jiang, H.; Feng, H.; Kwan, J.; Liu, X.; Wu, J.* “Photo-Induced Decarboxylative
Heck-Type Coupling of Unactivated Aliphatic Acids and Terminal Alkenes in the
Absence of Sacrificial Hydrogen Acceptors.” J. Am. Chem. Soc. 2018,
140, 16360-16367 (Highlighted by Synfacts 2019, 15,
0159; Org. Process Res. Dev. 2019, 23, 114-121; and X-MOL)
[23] Hou, J.; Ee, A.; Cao, H.; Ong, H.-W.; Xu, J.-H.; Wu, J.* “Visible-Light-Mediated
Metal-Free Difunctionalization of Alkenes with CO2 and Silanes or C(sp3)-H
Alkanes.” Angew. Chem. Int. Ed. 2018, 57, 17220-17224 (Selected as VIP paper in Angew. Chem. Int. Ed.; Highlighted
by Synfacts 2019, 15, 0198 and X-MOL, and WeeChem)
[24] Deng, H. P.; Zhou, Q.; Wu,
J.* “Micro-Tubing Reactor-Assisted Aliphatic C-H Functionalization Utilizing
HCl as the Hydrogen Atom Transfer Catalyst Precursor in Conjunction with an
Organo Photoredox Catalyst.” Angew. Chem. Int. Ed. 2018, 57,
12661-12665 (Highlighted by Synfacts 2018, 14, 1322 and
X-MOL)
[25] Wu, W. B.; Wong, Y. C.; Tan, Z. K.*; Wu, J.* “Photo-Induced Thiol Coupling and C-H Activation Using
Nanocrystalline Lead-Halide Perovskite Catalysts.” Catal. Sci. Technol. 2018, 8, 4257-4263
[26] Li, J. S.; Wu, J.* “Recent
Development of Photo-Mediated Generation of Silyl Radicals and Their
Application in Organic Synthesis.” ChemPhotoChem 2018, 2, 839-846 (Invited Review)
[27] Liu, H.; Ma, L.; Zhou, R.; Chen, X.*; Fang, W.; Wu, J.* “One-Pot Photo-Mediated Giese
Reaction/Friedel-Crafts Hydroxyalkylation/Oxidative Aromatization to Access
Naphthalene Derivatives from Toluenes and Enones.” ACS Catal. 2018, 8,
6224-6229 (Highlighted by X-MOL)
[28] Hou, J.; Li, J.; Wu, J.* “Recent
Development of Light-Mediated Carboxylation Using CO2 as the Feedstock.” Asian
J. Org. Chem. 2018, 7, 1439-1447 (Invited
Review)
[29] Fan, X.; Rong, J.; Wu, H.; Zhou, Q.; Deng, H.; Tan, J. D.; Xue,
C.; Wu, L,; Tao, H.; Wu, J.* “Eosin Y as
a Direct Hydrogen Atom Transfer Photocatalyst for the Functionalization of C-H
Bonds.” Angew. Chem. Int. Ed. 2018, 57, 8514-8518 (Highlighted by Angew. Chem. Int. Ed. 2019, 58, 378)
[30] Hou, J.; Ee, A.; Feng, W.; Xu, J.; Zhao, Y.*; Wu, J.* “Visible-Light-Driven Alkyne Hydro-/Carbocarboxylation Using
CO2 via Iridium/Cobalt Dual Catalysis for Divergent Heterocycle Synthesis.” J.
Am. Chem. Soc. 2018, 140, 5257-5263 (Highlighted
by X-MOL, featured in Organic Chemistry Portal)
[31] Toh, R. W.; Li, J. S.; Wu,
J.* “Utilization of Stop-flow Micro-tubing Reactors for the Development of
Organic Transformations.” J. Vis. Exp. 2018, 131, e56897
[32] Zhou, R.; Goh, Y. Y.; Liu, H.; Tao, H.; Li, L.; Wu, J.* “Visible-Light-Mediated
Metal-Free Hydrosilylation of Alkenes through Selective Hydrogen Atom Transfer
for Si-H Activation” Angew. Chem. Int. Ed. 2017, 56,
16621-16625 (Highlighted in Synfacts 2018, 14, 0819 and
X-MOL)
[33] Deng, H.; Fan, X.; Chen, Z.; Xu, Q.; Wu, J.* “Photo-Induced Nickel-Catalyzed Chemo- and Regioselective
Hydroalkylation of Internal Alkynes with Ether and Amide a-Hetero C(sp3)-H Bonds” J. Am. Chem. Soc. 2017,
139, 13579-13584 (Highlighted by X-MOL, NUS FoS, and
Phys.org)
[34] Zhou, R.; Liu, H.; Tao, H.; Yu, X.; Wu, J.* “Metal-Free Direct Alkylation of Unfunctionalized
Allylic/Benzylic sp3 C-H bonds via Photoredox Induced Radical Cation
Deprotonation” Chem. Sci. 2017, 8, 4654-4659 (Highlighted in Synfacts 2017, 13, 0819; most downloaded
articles of 2017 in Chem. Sci.)
[35] Xue, F.; Deng, H.; Xue, C.; Mohamed, D. K. B.; Tang, K. Y.; Wu, J.* “Reaction Discovery Using
Acetylene Gas as the Chemical Feedstock Accelerated by the ‘Stop-Flow’
Micro-Tubing Reactor System” Chem. Sci. 2017, 8, 3623-3627
[36] Ng. C. K.; Wu, J.*;
Hor, T. S.;* Luo, H.*“A Binary Catalyst System of a Cationic Ru-CNC Pincer Complex
with an Alkali Metal Salt for Selective Hydroboration of Carbon Dioxide” Chem. Commun. 2016, 52, 11842-11845
专利
1. Wu, J.; Khan, A. S.; Liu, C.; Wu, W.; Chen, W.; Wang, M.; Xie, J. “Method and System for Synthesising Compounds” US Provisional Patent Application No. 62/925,031.
2. Wu, J.; Li, J.; Xue, C.; Mohamed D. “Lotus-Type Reactor for Large-Scale Continuous-Flow and Stop-Flow Synthesis” Application No. 10201700300X.
3. Wu, J.; Deng H.; Xue, F.; Mohamed, D. “Modular ‘Stop-Flow’ Parallel Microtubing Reactor Platform Useful for High-Pressure Reaction Screening” US 62/320726.